[HTML][HTML] Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT)
AR Grassian, F Lin, R Barrett, Y Liu, W Jiang… - Journal of Biological …, 2012 - ASBMB
Mutations in the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a
variety of tumor types, resulting in production of the proposed oncometabolite, 2-
hydroxyglutarate (2-HG). How mutant IDH and 2-HG alter signaling pathways to promote
cancer, however, remains unclear. Additionally, there exist relatively few cell lines with IDH
mutations. To examine the effect of endogenous IDH mutations and 2-HG, we created a
panel of isogenic epithelial cell lines with either wild-type IDH1/2 or clinically relevant …
variety of tumor types, resulting in production of the proposed oncometabolite, 2-
hydroxyglutarate (2-HG). How mutant IDH and 2-HG alter signaling pathways to promote
cancer, however, remains unclear. Additionally, there exist relatively few cell lines with IDH
mutations. To examine the effect of endogenous IDH mutations and 2-HG, we created a
panel of isogenic epithelial cell lines with either wild-type IDH1/2 or clinically relevant …