[HTML][HTML] Impaired response of biliary lipid secretion to a lithogenic diet in phosphatidylcholine transfer protein-deficient mice
MK Wu, H Hyogo, SK Yadav, PM Novikoff… - Journal of lipid …, 2005 - ASBMB
Phosphatidylcholine transfer protein (PC-TP) is a cytosolic lipid transfer protein that is highly
expressed in liver and catalyzes intermembrane transfer of phosphatidylcholines in vitro. To
explore a role for PC-TP in the hepatocellular trafficking of biliary phosphatidylcholines, we
characterized biliary lipid secretion using Pctp−/− and wild-type littermate control mice with
C57BL/6J and FVB/NJ genetic backgrounds, which express PC-TP at relatively high and low
levels in liver, respectively. Eight-week-old male Pctp−/− and wild-type mice were fed a …
expressed in liver and catalyzes intermembrane transfer of phosphatidylcholines in vitro. To
explore a role for PC-TP in the hepatocellular trafficking of biliary phosphatidylcholines, we
characterized biliary lipid secretion using Pctp−/− and wild-type littermate control mice with
C57BL/6J and FVB/NJ genetic backgrounds, which express PC-TP at relatively high and low
levels in liver, respectively. Eight-week-old male Pctp−/− and wild-type mice were fed a …
