Diagnostic challenges in chronic antibody-mediated rejection

EA Farkash, RB Colvin - Nature reviews Nephrology, 2012 - nature.com
EA Farkash, RB Colvin
Nature reviews Nephrology, 2012nature.com
Measurement of glomerular and peritubular capillaritis in kidney transplant biopsy samples
identifies allograft dysfunction associated with alloantibodies. Sis et al. show that this
technique has a higher sensitivity but lower specificity than the current diagnostic criteria
using peritubular capillary C4d deposition, and that capillaritis is an independent predictor of
progression to graft failure.
Measurement of glomerular and peritubular capillaritis in kidney transplant biopsy samples identifies allograft dysfunction associated with alloantibodies. Sis et al. show that this technique has a higher sensitivity but lower specificity than the current diagnostic criteria using peritubular capillary C4d deposition, and that capillaritis is an independent predictor of progression to graft failure.
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