DNA copy number variants: a potentially useful predictor of early onset renal failure in boys with posterior urethral valves
A Faure, A Bouty, G Caruana, L Williams… - Journal of pediatric …, 2016 - Elsevier
Introduction Posterior urethral valves (PUV) are among the most common urological causes
of chronic kidney disease (CKD) in childhood. Recently, genomic imbalances have been
cited as potential risk factors for altered kidney function and have been associated with CKD.
The phenotypic effects of a copy number variant (CNV) in boys with PUV are unknown.
Here, it was hypothesised that the progression to early renal failure in PUV patients may be
influenced by genetic aberrations. Objective To assess the relationship between CNVs and …
of chronic kidney disease (CKD) in childhood. Recently, genomic imbalances have been
cited as potential risk factors for altered kidney function and have been associated with CKD.
The phenotypic effects of a copy number variant (CNV) in boys with PUV are unknown.
Here, it was hypothesised that the progression to early renal failure in PUV patients may be
influenced by genetic aberrations. Objective To assess the relationship between CNVs and …