[HTML][HTML] Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress …
S Jiang, C Yan, Q Fang, Y Zhang, Y Liu, Y Deng… - Journal of Biological …, 2014 - ASBMB
Endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR)
and represents a critical mechanism that underlies metabolic dysfunctions. Fibroblast growth
factor 21 (FGF21), a hormone that is predominantly secreted by the liver, exerts a broad
range of effects upon the metabolism of carbohydrates and lipids. Although increased
circulating levels of FGF21 have been documented in animal models and human subjects
with obesity and nonalcoholic fatty liver disease, the functional interconnections between …
and represents a critical mechanism that underlies metabolic dysfunctions. Fibroblast growth
factor 21 (FGF21), a hormone that is predominantly secreted by the liver, exerts a broad
range of effects upon the metabolism of carbohydrates and lipids. Although increased
circulating levels of FGF21 have been documented in animal models and human subjects
with obesity and nonalcoholic fatty liver disease, the functional interconnections between …