N-terminal truncation of NPY has important physiological consequences, because the
truncated peptides lose their capability to activate the Y1-receptor. The sources of N-
terminally truncated NPY and related peptides are unknown and several proline specific
peptidases may be involved. First, we therefore provide an overview on the peptidases,
belonging to structural and functional homologues of dipeptidyl peptidase 4 (DP4) as well as
aminopeptidase P (APP) and thus, represent potential candidates of NPY cleavage in vivo …