We recently reported the importance of Synoviolin in quality control of proteins through the
endoplasmic reticulum (ER)-associated degradation (ERAD) system and its involvement in
the pathogenesis of arthropathy through its anti-apoptotic effect. For further understanding of
the role of Synoviolin in vivo, we generated in this study synoviolin-deficient (syno–/–) mice
by genetargeted disruption. Strikingly, all fetuses lacking syno died in utero around
embryonic day 13.5, although Hrd1p, a yeast orthologue of Synoviolin, is non-essential for …