Association between osteocalcin gamma-carboxylation and insulin resistance in overweight and obese postmenopausal women
Aim In mice, osteocalcin (OCN) acts as a bone-derived hormone promoting insulin
sensitivity and glucose tolerance. In that species, OCN endocrine action is inhibited when its
first glutamic acid residue (Glu13) is γ-carboxylated (Gla). The importance of this
posttranslational modification for OCN function in human is still unclear. Our objectives were
to identify an assay to assess γ-carboxylation of human OCN on its first Glu residue (Glu17)
and to test its association with insulin resistance and inflammation profile in overweight …
sensitivity and glucose tolerance. In that species, OCN endocrine action is inhibited when its
first glutamic acid residue (Glu13) is γ-carboxylated (Gla). The importance of this
posttranslational modification for OCN function in human is still unclear. Our objectives were
to identify an assay to assess γ-carboxylation of human OCN on its first Glu residue (Glu17)
and to test its association with insulin resistance and inflammation profile in overweight …