mRNA translation plays a central role in the regulation of gene expression and represents
the most energy consuming process in mammalian cells. Accordingly, dysregulation of
mRNA translation is considered to play a major role in a variety of pathological states
including cancer. Ribosomes also host chaperones, which facilitate folding of nascent
polypeptides, thereby modulating function and stability of newly synthesized polypeptides. In
addition, emerging data indicate that ribosomes serve as a platform for a repertoire of …