FOXO transcription factors: key regulators of cellular quality control

AE Webb, A Brunet - Trends in biochemical sciences, 2014 - cell.com
Trends in biochemical sciences, 2014cell.com
FOXO transcription factors are conserved regulators of longevity downstream of insulin
signaling. These transcription factors integrate signals emanating from nutrient deprivation
and stress stimuli to coordinate programs of genes involved in cellular metabolism and
resistance to oxidative stress. Here, we discuss emerging evidence for a pivotal role of
FOXO factors in promoting the expression of genes involved in autophagy and the ubiquitin–
proteasome system–two cell clearance processes that are essential for maintaining …
FOXO transcription factors are conserved regulators of longevity downstream of insulin signaling. These transcription factors integrate signals emanating from nutrient deprivation and stress stimuli to coordinate programs of genes involved in cellular metabolism and resistance to oxidative stress. Here, we discuss emerging evidence for a pivotal role of FOXO factors in promoting the expression of genes involved in autophagy and the ubiquitin–proteasome system – two cell clearance processes that are essential for maintaining organelle and protein homeostasis (proteostasis). The ability of FOXO to maintain cellular quality control appears to be critical in processes and pathologies where damaged proteins and organelles accumulate, including aging and neurodegenerative diseases.
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