[HTML][HTML] Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function
Tamm-Horsfall glycoprotein (THGP) or Uromodulin is a membrane protein exclusively
expressed along the thick ascending limb (TAL) and early distal convoluted tubule (DCT) of
the nephron. Mutations in the THGP encoding gene result in Familial Juvenile
Hyperuricemic Nephropathy (FJHN), Medullary Cystic Kidney Disease type 2 (MCKD-2),
and Glomerulocystic Kidney Disease (GCKD). The physicochemical and biological
properties of THGP have been studied extensively, but its physiological function in the TAL …
expressed along the thick ascending limb (TAL) and early distal convoluted tubule (DCT) of
the nephron. Mutations in the THGP encoding gene result in Familial Juvenile
Hyperuricemic Nephropathy (FJHN), Medullary Cystic Kidney Disease type 2 (MCKD-2),
and Glomerulocystic Kidney Disease (GCKD). The physicochemical and biological
properties of THGP have been studied extensively, but its physiological function in the TAL …