Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

A Fazeli, SL Dickinson, ML Hermiston, RV Tighe… - Nature, 1997 - nature.com
A Fazeli, SL Dickinson, ML Hermiston, RV Tighe, RG Steen, CG Small, ET Stoeckli
Nature, 1997nature.com
The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-
suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have
provided evidence that DCC might function as a receptor for the axonal chemoattractant
netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are
similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation,
morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a …
Abstract
The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.
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