[HTML][HTML] NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and …
E Liepinsh, L Bányai, G Pintacuda, M Trexler… - Journal of Biological …, 2003 - ASBMB
Procollagen C-proteinase enhancer (PCOLCE) proteins are extracellular matrix proteins that
enhance the activities of procollagen C-proteinases by binding to the C-propeptide of
procollagen I. PCOLCE proteins are built of three structural modules, consisting of two CUB
domains followed by a C-terminal netrin-like (NTR) domain. While the enhancement of
proteinase activity can be ascribed solely to the CUB domains, sequence homology of the
NTR domain with tissue inhibitors of metalloproteinases suggest proteinase inhibitory …
enhance the activities of procollagen C-proteinases by binding to the C-propeptide of
procollagen I. PCOLCE proteins are built of three structural modules, consisting of two CUB
domains followed by a C-terminal netrin-like (NTR) domain. While the enhancement of
proteinase activity can be ascribed solely to the CUB domains, sequence homology of the
NTR domain with tissue inhibitors of metalloproteinases suggest proteinase inhibitory …