[HTML][HTML] Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium
Z Wang, C Friedrich, SC Hagemann, WH Korte… - Mucosal …, 2014 - Elsevier
Intestinal infection with the mouse pathogen Citrobacter rodentium induces a strong local
Th17 response in the colon. Although this inflammatory immune response helps to clear the
pathogen, it also induces inflammation-associated pathology in the gut and thus, has to be
tightly controlled. In this project, we therefore studied the impact of Foxp3+ regulatory T cells
(Treg) on the infectious and inflammatory processes elicited by the bacterial pathogen C.
rodentium. Surprisingly, we found that depletion of Treg by diphtheria toxin in the Foxp3 …
Th17 response in the colon. Although this inflammatory immune response helps to clear the
pathogen, it also induces inflammation-associated pathology in the gut and thus, has to be
tightly controlled. In this project, we therefore studied the impact of Foxp3+ regulatory T cells
(Treg) on the infectious and inflammatory processes elicited by the bacterial pathogen C.
rodentium. Surprisingly, we found that depletion of Treg by diphtheria toxin in the Foxp3 …