Neural progenitor cells regulate microglia functions and activity
Nature neuroscience, 2012•nature.com
We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct
from other brain cells and to modulate microglial activation, proliferation and phagocytosis.
NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at
least some of these effects in mice. Thus, neural precursor cells may not only be shaped by
microglia, but also regulate microglia functions and activity.
from other brain cells and to modulate microglial activation, proliferation and phagocytosis.
NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at
least some of these effects in mice. Thus, neural precursor cells may not only be shaped by
microglia, but also regulate microglia functions and activity.
Abstract
We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity.
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