IgE crosslinkage of Fcε receptor I induces both production and activation of matrix metalloproteinase-9 in mast cells
A Tanaka, H Matsuda - Cellular immunology, 2004 - Elsevier
Since mast cells play pivotal roles in allergic inflammations, we investigated how IgE-
mediated stimulation modulated mast cell matrix metalloproteinase (MMP)-9 production, and
its enzymatic activation. In this study, we clearly demonstrated that proMMP-9 released from
murine bone marrow-derived cultured mast cells (BMCMC) was activated to its valid form
after crosslinking of surface immunoglobulin (Ig) E. Serine protease inhibitors sensitive to
chymases inhibited the phenomenon, indicating that certain chymases may be responsible …
mediated stimulation modulated mast cell matrix metalloproteinase (MMP)-9 production, and
its enzymatic activation. In this study, we clearly demonstrated that proMMP-9 released from
murine bone marrow-derived cultured mast cells (BMCMC) was activated to its valid form
after crosslinking of surface immunoglobulin (Ig) E. Serine protease inhibitors sensitive to
chymases inhibited the phenomenon, indicating that certain chymases may be responsible …