[HTML][HTML] Endoplasmic reticulum stress-induced apoptosis in Leishmania through Ca2+-dependent and caspase-independent mechanism
Numerous reports have shown that mitochondrial dysfunctions play a major role in
apoptosis of Leishmania parasites, but the endoplasmic reticulum (ER) stress-induced
apoptosis in Leishmania remains largely unknown. In this study, we investigate ER stress-
induced apoptotic pathways in Leishmania major using tunicamycin as an ER stress
inducer. ER stress activates the expression of ER-localized chaperone protein BIP/GRP78
(binding protein/identical to the 78-kDa glucose-regulated protein) with concomitant …
apoptosis of Leishmania parasites, but the endoplasmic reticulum (ER) stress-induced
apoptosis in Leishmania remains largely unknown. In this study, we investigate ER stress-
induced apoptotic pathways in Leishmania major using tunicamycin as an ER stress
inducer. ER stress activates the expression of ER-localized chaperone protein BIP/GRP78
(binding protein/identical to the 78-kDa glucose-regulated protein) with concomitant …