A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic inflammatory disorder with many
genetic factors predisposing to disease susceptibility. MicroRNAs are a new discovered
class of molecules that participate in post-transcriptional regulation of genes' expression.
MicroRNA-146a was found to be increased in synovial fibroblasts, synovial tissue and
PBMC from patients with RA. The aim of the present study was to reveal if there is any
association of miRNA-146a variant rs2910164 and the two interleukin (IL) 1 receptor …
genetic factors predisposing to disease susceptibility. MicroRNAs are a new discovered
class of molecules that participate in post-transcriptional regulation of genes' expression.
MicroRNA-146a was found to be increased in synovial fibroblasts, synovial tissue and
PBMC from patients with RA. The aim of the present study was to reveal if there is any
association of miRNA-146a variant rs2910164 and the two interleukin (IL) 1 receptor …