Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia
Importance Tests that predict outcomes for patients with acute myeloid leukemia (AML) are
imprecise, especially for those with intermediate risk AML. Objectives To determine whether
genomic approaches can provide novel prognostic information for adult patients with de
novo AML. Design, Setting, and Participants Whole-genome or exome sequencing was
performed on samples obtained at disease presentation from 71 patients with AML (mean
age, 50.8 years) treated with standard induction chemotherapy at a single site starting in …
imprecise, especially for those with intermediate risk AML. Objectives To determine whether
genomic approaches can provide novel prognostic information for adult patients with de
novo AML. Design, Setting, and Participants Whole-genome or exome sequencing was
performed on samples obtained at disease presentation from 71 patients with AML (mean
age, 50.8 years) treated with standard induction chemotherapy at a single site starting in …