In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems
HY Meltzer, M Huang - Progress in brain research, 2008 - Elsevier
Atypical antipsychotic drugs related to clozapine, improve psychosis, cognition and negative
symptoms, while producing minimal extrapyramidal side effects, in patients with
schizophrenia. This appears to be mediated mainly through the combined effect of relatively
more potent blockade of 5-HT 2A receptors, located on cortical and hippocampal
glutamatergic and GABAergic neurons, as well as cell bodies of the mesolimbic and
mesocortical dopamine (DA) neurons, and weaker blockade of D 2 receptors in the ventral …
symptoms, while producing minimal extrapyramidal side effects, in patients with
schizophrenia. This appears to be mediated mainly through the combined effect of relatively
more potent blockade of 5-HT 2A receptors, located on cortical and hippocampal
glutamatergic and GABAergic neurons, as well as cell bodies of the mesolimbic and
mesocortical dopamine (DA) neurons, and weaker blockade of D 2 receptors in the ventral …