Toll-like receptors in Alzheimer's disease
GE Landreth, EG Reed-Geaghan - Toll-like receptors: Roles in infection …, 2009 - Springer
Toll-like receptors: Roles in infection and neuropathology, 2009•Springer
Alzheimer's disease (AD) is characterized by the formation of insoluble deposits of β-
amyloid (Aβ) within the parenchyma of the brain. These deposits are associated with a
robust microglia-mediated inflammatory response. Recent work has demonstrated that Toll-
like receptors (TLRs) participate in this inflammatory response. This chapter reviews the
mechanisms whereby TLRs contribute to the induction of a microglial inflammatory response
to promote AD pathogenesis. Specifically, the involvement of CD14 and the TLRs in …
amyloid (Aβ) within the parenchyma of the brain. These deposits are associated with a
robust microglia-mediated inflammatory response. Recent work has demonstrated that Toll-
like receptors (TLRs) participate in this inflammatory response. This chapter reviews the
mechanisms whereby TLRs contribute to the induction of a microglial inflammatory response
to promote AD pathogenesis. Specifically, the involvement of CD14 and the TLRs in …
Abstract
Alzheimer’s disease (AD) is characterized by the formation of insoluble deposits of β-amyloid (Aβ) within the parenchyma of the brain. These deposits are associated with a robust microglia-mediated inflammatory response. Recent work has demonstrated that Toll-like receptors (TLRs) participate in this inflammatory response. This chapter reviews the mechanisms whereby TLRs contribute to the induction of a microglial inflammatory response to promote AD pathogenesis. Specifically, the involvement of CD14 and the TLRs in microglial activation is delineated. The TLR-mediated microglial response has beneficial roles in stimulating phagocytosis as well as detrimental roles in the Aβ-stimulated release of neurotoxic products.
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