Prognostic immune markers in non–small cell lung cancer

K Suzuki, SS Kachala, K Kadota, R Shen, Q Mo… - Clinical Cancer …, 2011 - AACR
K Suzuki, SS Kachala, K Kadota, R Shen, Q Mo, DG Beer, VW Rusch, WD Travis
Clinical Cancer Research, 2011AACR
Tumor-associated immune responses have polarized effects in regulating tumor growth.
Although a clear association has been shown between the tumor immune response and
clinical outcome in colorectal and ovarian cancers, the role of immune markers for stratifying
prognosis in non–small cell lung cancer (NSCLC) is less defined. Herein, we review the
prognostic significance of published immune markers in the tumor microenvironment and
peripheral blood of NSCLC patients. To identify prognostic immune genes, we reviewed all …
Abstract
Tumor-associated immune responses have polarized effects in regulating tumor growth. Although a clear association has been shown between the tumor immune response and clinical outcome in colorectal and ovarian cancers, the role of immune markers for stratifying prognosis in non–small cell lung cancer (NSCLC) is less defined. Herein, we review the prognostic significance of published immune markers in the tumor microenvironment and peripheral blood of NSCLC patients. To identify prognostic immune genes, we reviewed all published gene-profiling studies in NSCLC and delineated the significance of immune genes by doing subanalysis on the microarray database of the NIH Director's Challenge study. This first comprehensive review of prognostic immune markers provides a foundation for further investigating immune responses in NSCLC. Clin Cancer Res; 17(16); 5247–56. ©2011 AACR.
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