CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes: Implications for HLA class I and II …
D Ou, LA Jonsen, DL Metzger, AJ Tingle - Human immunology, 1999 - Elsevier
To fully characterize human glutamic acid decarboxylase (GAD) 65 protein T-cell epitopes
associated with insulin-dependent diabetes mellitus (IDDM), CTL clones specific to GAD65
protein antigens were isolated from two congenital rubella syndrome (CRS)-associated
IDDM patients. Overlapping nonamer T-cell epitopes recognized by both CD4+ or CD8+
CTL clones within peptides GAD65 (252-266) and GAD65 (274-286) were identified as
sequences bounded by GAD65 (255-266) with 6/9 overlapping residues, and GAD65 (276 …
associated with insulin-dependent diabetes mellitus (IDDM), CTL clones specific to GAD65
protein antigens were isolated from two congenital rubella syndrome (CRS)-associated
IDDM patients. Overlapping nonamer T-cell epitopes recognized by both CD4+ or CD8+
CTL clones within peptides GAD65 (252-266) and GAD65 (274-286) were identified as
sequences bounded by GAD65 (255-266) with 6/9 overlapping residues, and GAD65 (276 …