The hierarchical model of NAFLD: prognostic significance of histologic features in NASH
R Loomba, N Chalasani - Gastroenterology, 2015 - gastrojournal.org
Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver
disease in the United States. 1–3 It has been broadly subdivided into 2 categories including
nonalcoholic fatty liver, which is considered to be the milder phenotype with lower risk of
progression to cirrhosis, and nonalcoholic steatohepatitis (NASH), which is considered to be
the more advanced phenotype with substantial risk of progression to cirrhosis. 3, 4 Recent
studies have suggested that some patients with NAFLD may rapidly progress to cirrhosis …
disease in the United States. 1–3 It has been broadly subdivided into 2 categories including
nonalcoholic fatty liver, which is considered to be the milder phenotype with lower risk of
progression to cirrhosis, and nonalcoholic steatohepatitis (NASH), which is considered to be
the more advanced phenotype with substantial risk of progression to cirrhosis. 3, 4 Recent
studies have suggested that some patients with NAFLD may rapidly progress to cirrhosis …