Novel 3D magnetic resonance elastography for the noninvasive diagnosis of advanced fibrosis in NAFLD: a prospective study
R Loomba, J Cui, T Wolfson, W Haufe… - Official journal of the …, 2016 - journals.lww.com
Official journal of the American College of Gastroenterology| ACG, 2016•journals.lww.com
OBJECTIVES: Recent studies show two-dimensional (2D)-magnetic resonance
elastography (MRE) is accurate in diagnosing advanced fibrosis (stages 3 and 4) in
nonalcoholic fatty liver disease (NAFLD) patients. Three-dimensional (3D)-MRE is a more
advanced version of the technology that can image shear-wave fields in 3D of the entire
liver. The aim of this study was to prospectively compare the diagnostic accuracy of 3D-MRE
and 2D-MRE for diagnosing advanced fibrosis in patients with biopsy-proven NAFLD …
elastography (MRE) is accurate in diagnosing advanced fibrosis (stages 3 and 4) in
nonalcoholic fatty liver disease (NAFLD) patients. Three-dimensional (3D)-MRE is a more
advanced version of the technology that can image shear-wave fields in 3D of the entire
liver. The aim of this study was to prospectively compare the diagnostic accuracy of 3D-MRE
and 2D-MRE for diagnosing advanced fibrosis in patients with biopsy-proven NAFLD …
Abstract
OBJECTIVES:
Recent studies show two-dimensional (2D)-magnetic resonance elastography (MRE) is accurate in diagnosing advanced fibrosis (stages 3 and 4) in nonalcoholic fatty liver disease (NAFLD) patients. Three-dimensional (3D)-MRE is a more advanced version of the technology that can image shear-wave fields in 3D of the entire liver. The aim of this study was to prospectively compare the diagnostic accuracy of 3D-MRE and 2D-MRE for diagnosing advanced fibrosis in patients with biopsy-proven NAFLD.
METHODS:
This cross-sectional analysis of a prospective study included 100 consecutive patients (56% women) with biopsy-proven NAFLD who also underwent MRE. Area under the receiver operating characteristic (AUROC) analysis was performed to assess the accuracy of 2D-and 3D-MRE in diagnosing advanced fibrosis.
RESULTS:
Lippincott Williams & Wilkins