[PDF][PDF] Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide

EY Choi, GJ Christianson, Y Yoshimura, TJ Sproule… - Immunity, 2002 - cell.com
EY Choi, GJ Christianson, Y Yoshimura, TJ Sproule, N Jung, S Joyce, DC Roopenian
Immunity, 2002cell.com
The H60 minor histocompatibility (H) antigen peptide is derived from a glycoprotein that
serves as a ligand for the stimulatory NKG2D receptor. We show that this peptide is
remarkably immunodominant in that it competes effectively with MHC alloantigens, is
efficiently crosspresented by host antigen-presenting cells (APCs), and readily elicits naive
CD8 T cell responses in vitro. H60 immunodominance is neither a consequence of NKG2D
engagement nor competition among minor H antigens on APCs. Instead, H60 …
Abstract
The H60 minor histocompatibility (H) antigen peptide is derived from a glycoprotein that serves as a ligand for the stimulatory NKG2D receptor. We show that this peptide is remarkably immunodominant in that it competes effectively with MHC alloantigens, is efficiently crosspresented by host antigen-presenting cells (APCs), and readily elicits naive CD8 T cell responses in vitro. H60 immunodominance is neither a consequence of NKG2D engagement nor competition among minor H antigens on APCs. Instead, H60 immunodominance is a consequence of an abnormally high naive precursor frequency of H60 peptide reactive CD8 T cells. Understanding why the H60 peptide is so immunogenic has important implications in tissue transplantation and vaccine design.
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