[HTML][HTML] Unveiling the roles of autophagy in innate and adaptive immunity

B Levine, V Deretic - Nature Reviews Immunology, 2007 - nature.com
Nature Reviews Immunology, 2007nature.com
Cells digest portions of their interiors in a process known as autophagy to recycle nutrients,
remodel and dispose of unwanted cytoplasmic constituents. This ancient pathway,
conserved from yeast to humans, is now emerging as a central player in the immunological
control of bacterial, parasitic and viral infections. The process of autophagy may degrade
intracellular pathogens, deliver endogenous antigens to MHC-class-II-loading
compartments, direct viral nucleic acids to Toll-like receptors and regulate T-cell …
Abstract
Cells digest portions of their interiors in a process known as autophagy to recycle nutrients, remodel and dispose of unwanted cytoplasmic constituents. This ancient pathway, conserved from yeast to humans, is now emerging as a central player in the immunological control of bacterial, parasitic and viral infections. The process of autophagy may degrade intracellular pathogens, deliver endogenous antigens to MHC-class-II-loading compartments, direct viral nucleic acids to Toll-like receptors and regulate T-cell homeostasis. This Review describes the mechanisms of autophagy and highlights recent advances relevant to the role of autophagy in innate and adaptive immunity.
nature.com