Interleukin‐17 regulates the expressions of RANKL and OPG in human periodontal ligament cells via TRAF6/TBK1‐JNK/NF‐κB pathways
D Lin, L Li, Y Sun, W Wang, X Wang, Y Ye… - …, 2015 - Wiley Online Library
Summary Interleukin‐17 (IL‐17 or IL‐17A), a pleiotropic cytokine produced by T helper type
17 cells, is involved in the pathogenesis of various autoimmune and inflammatory disorders,
including periodontitis. Although the ability of pro‐inflammation in periodontitis has been
widely investigated, the other biological functions of IL‐17, including its role in bone
remodelling and the underlying molecular mechanisms, have not been well clarified. In the
present study, IL‐17 could significantly enhance the expression of receptor activator for …
17 cells, is involved in the pathogenesis of various autoimmune and inflammatory disorders,
including periodontitis. Although the ability of pro‐inflammation in periodontitis has been
widely investigated, the other biological functions of IL‐17, including its role in bone
remodelling and the underlying molecular mechanisms, have not been well clarified. In the
present study, IL‐17 could significantly enhance the expression of receptor activator for …
IL-17 regulates the expressions of RANKL and OPG in human periodontal ligament cells via TRAF6/TBK1-JNK/NF-κB pathways.
D Lin, L Li, Y Sun, W Wang, X Wang, Y Ye, X Chen… - Immunology, 2014 - europepmc.org
Interleukin-17 (IL-17 or IL-17A), a pleiotropic cytokine produced by T helper (Th) 17 cells, is
involved in the pathogenesis of various autoimmune and inflammatory disorders, including
periodontitis. Although the ability of pro-inflammation in periodontitis have been widely
investigated, the other biological functions of IL-17, including its role in bone remodeling and
the underlying molecular mechanism, have not been well clarified. In the present study, IL-
17 could significantly enhance the expression of receptor activator for nuclear factor-κB …
involved in the pathogenesis of various autoimmune and inflammatory disorders, including
periodontitis. Although the ability of pro-inflammation in periodontitis have been widely
investigated, the other biological functions of IL-17, including its role in bone remodeling and
the underlying molecular mechanism, have not been well clarified. In the present study, IL-
17 could significantly enhance the expression of receptor activator for nuclear factor-κB …