An economy of water in renal function referable to urea

JL Gamble, CF McKhann… - American Journal of …, 1934 - journals.physiology.org
JL Gamble, CF McKhann, AM Butler, E Tuthill
American Journal of Physiology-Legacy Content, 1934journals.physiology.org
The data sought were measurements of the concentration in the urine of substances added
singly and as mixtures to the basal diet. To this end two substances were used in each
experiment. The experiment was begun by adding one of the substances to the diet. Then in
successive periods this substance was progressively, and in the final period entirely,
replaced by the other substance. In all of the experiments, except those in which glucose
was studied, the sum of the osmolar values of the substances added to the diet remained the …
The data sought were measurements of the concentration in the urine of substances added singly and as mixtures to the basal diet. To this end two substances were used in each experiment. The experiment was begun by adding one of the substances to the diet. Then in successive periods this substance was progressively, and in the final period entirely, replaced by the other substance. In all of the experiments, except those in which glucose was studied, the sum of the osmolar values of the substances added to the diet remained the same throughout the experiment. Each period occupied five days, the measurements being obtained from urine collected over the last three days. The basal diet used was of the purified type, being composed of casein, milk fat, corn starch, yeast and a salt mixture? Since each experiment extended over a number of weeks it was necessary that the basal diet be
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