[CITATION][C] Phosphorylation, allosteric effectors and inter-domain contacts in CAD; their role in regulation of early steps of pyrimidine biosynthesis

EA Carrey - Biochemical Society Transactions, 1993 - portlandpress.com
EA Carrey
Biochemical Society Transactions, 1993portlandpress.com
The multienzyme polypeptide CAD comprises the following enzyme activities: glutamine-
dependent carbamyl phosphate synthetase (CPSase 11), aspartate transcarbamylase
(ATCase) and dihydroorotase (DHOase). The appropriate domains of the polypeptide thus
catalyse sequentially the first steps of pyrimidine biosynthesis in mammals. Figure 1
illustrates the concept of the molecule that we have
The multienzyme polypeptide CAD comprises the following enzyme activities: glutamine-dependent carbamyl phosphate synthetase (CPSase 11), aspartate transcarbamylase (ATCase) and dihydroorotase (DHOase). The appropriate domains of the polypeptide thus catalyse sequentially the first steps of pyrimidine biosynthesis in mammals. Figure 1 illustrates the concept of the molecule that we have
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