[HTML][HTML] The human estrogen receptor-α is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor …
AL Wijayaratne, DP McDonnell - Journal of Biological Chemistry, 2001 - ASBMB
The human estrogen receptor α-isoform (ERα) is a nuclear transcription factor that displays a
complex pharmacology. In addition to classical agonists and antagonists, the transcriptional
activity of ERα can be regulated by selective estrogen receptor modulators, a new class of
drugs whose relative agonist/antagonist activity is determined by cell context. It has been
demonstrated that the binding of different ligands to ERα results in the formation of unique
ERα-ligand conformations. These conformations have been shown to influence ERα …
complex pharmacology. In addition to classical agonists and antagonists, the transcriptional
activity of ERα can be regulated by selective estrogen receptor modulators, a new class of
drugs whose relative agonist/antagonist activity is determined by cell context. It has been
demonstrated that the binding of different ligands to ERα results in the formation of unique
ERα-ligand conformations. These conformations have been shown to influence ERα …