Control of energy balance by the brain renin-angiotensin system

KE Claflin, JL Grobe - Current hypertension reports, 2015 - Springer
Current hypertension reports, 2015Springer
The renin-angiotensin system (RAS) exists as a circulating hormone system but it is also
used by various tissues of the body, including the brain, as a paracrine signaling
mechanism. The local brain version of the RAS is mechanistically involved in fluid balance
and blood pressure control, and there is growing appreciation for a role of the brain RAS in
the control of energy balance. Here, we review major evidence for the control of energy
balance by the brain RAS; outline the current understanding of the RAS components …
Abstract
The renin-angiotensin system (RAS) exists as a circulating hormone system but it is also used by various tissues of the body, including the brain, as a paracrine signaling mechanism. The local brain version of the RAS is mechanistically involved in fluid balance and blood pressure control, and there is growing appreciation for a role of the brain RAS in the control of energy balance. Here, we review major evidence for the control of energy balance by the brain RAS; outline the current understanding of the RAS components, targets, and mechanisms involved; and highlight some major questions that currently face the field.
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