[HTML][HTML] GLP-1 based therapeutics: simultaneously combating T2DM and obesity

KM Heppner, D Perez-Tilve - Frontiers in neuroscience, 2015 - frontiersin.org
KM Heppner, D Perez-Tilve
Frontiers in neuroscience, 2015frontiersin.org
Glucagon-like peptide-1 (GLP-1) enhances meal-related insulin secretion, which lowers
blood glucose excursions. In addition to its incretin action, GLP-1 acts on the GLP-1 receptor
(GLP-1R) in the brain to suppress feeding. These combined actions of GLP-1R signaling
cause improvements in glycemic control as well as weight loss in type II diabetes (T2DM)
patients treated with GLP-1R agonists. This is a superior advantage of GLP-1R
pharmaceuticals as many other drugs used to treat T2DM are weight neutral or actual cause …
Glucagon-like peptide-1 (GLP-1) enhances meal-related insulin secretion, which lowers blood glucose excursions. In addition to its incretin action, GLP-1 acts on the GLP-1 receptor (GLP-1R) in the brain to suppress feeding. These combined actions of GLP-1R signaling cause improvements in glycemic control as well as weight loss in type II diabetes (T2DM) patients treated with GLP-1R agonists. This is a superior advantage of GLP-1R pharmaceuticals as many other drugs used to treat T2DM are weight neutral or actual cause weight gain. This review summarizes GLP-1R action on energy and glucose metabolism, the effectiveness of current GLP-1R agonists on weight loss in T2DM patients, as well as GLP-1R combination therapies.
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