[HTML][HTML] Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1
The cytoplasmic adaptor protein Disabled-1 (Dab1) is necessary for the regulation of
neuronal positioning in the developing brain by the secreted molecule Reelin. Binding of
Reelin to the neuronal apolipoprotein E receptors apoER2 and very low density lipoprotein
receptor induces tyrosine phosphorylation of Dab1 and the subsequent activation or
relocalization of downstream targets like phosphatidylinositol 3 (PI3)-kinase and Nckβ.
Disruption of Reelin signaling leads to the accumulation of Dab1 protein in the brains of …
neuronal positioning in the developing brain by the secreted molecule Reelin. Binding of
Reelin to the neuronal apolipoprotein E receptors apoER2 and very low density lipoprotein
receptor induces tyrosine phosphorylation of Dab1 and the subsequent activation or
relocalization of downstream targets like phosphatidylinositol 3 (PI3)-kinase and Nckβ.
Disruption of Reelin signaling leads to the accumulation of Dab1 protein in the brains of …