Diacylglycerol-mediated insulin resistance

DM Erion, GI Shulman - Nature medicine, 2010 - nature.com
DM Erion, GI Shulman
Nature medicine, 2010nature.com
Understanding the molecular mechanisms of insulin resistance remains a major medical
challenge of the twenty-first century. Over the last half-century, many hypotheses have been
proposed to explain insulin resistance, and, most recently, inflammation associated with
alterations in adipocytokines has become the prevailing hypothesis. Here we discuss
diacylglycerol-mediated insulin resistance as an alternative and unifying hypothesis to
explain the most common forms of insulin resistance associated with obesity and type 2 …
Abstract
Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to explain insulin resistance, and, most recently, inflammation associated with alterations in adipocytokines has become the prevailing hypothesis. Here we discuss diacylglycerol-mediated insulin resistance as an alternative and unifying hypothesis to explain the most common forms of insulin resistance associated with obesity and type 2 diabetes mellitus, as well as lipodystrophy and aging.
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