A 10‐item smell identification scale related to risk for Alzheimer's disease

MH Tabert, X Liu, RL Doty, M Serby… - Annals of …, 2005 - Wiley Online Library
MH Tabert, X Liu, RL Doty, M Serby, D Zamora, GH Pelton, K Marder, MW Albers, Y Stern
Annals of neurology, 2005Wiley Online Library
Abstract University of Pennsylvania Smell Identification Test data from control subjects (n=
63), patients with mild cognitive impairment (n= 147), and patients with Alzheimer's disease
(n= 100) were analyzed to derive an optimal subset of items related to risk for Alzheimer's
disease (ie, healthy through mild cognitive impairment to early and moderate disease
stages). The derived 10‐item scale performed comparably with the University of
Pennsylvania Smell Identification Test in classifying subjects, and it strongly predicted …
Abstract
University of Pennsylvania Smell Identification Test data from control subjects (n = 63), patients with mild cognitive impairment (n = 147), and patients with Alzheimer's disease (n = 100) were analyzed to derive an optimal subset of items related to risk for Alzheimer's disease (ie, healthy through mild cognitive impairment to early and moderate disease stages). The derived 10‐item scale performed comparably with the University of Pennsylvania Smell Identification Test in classifying subjects, and it strongly predicted conversion to Alzheimer's disease on follow‐up evaluation in patients with mild cognitive impairment. Independent replication is needed to validate these findings. Ann Neurol 2005;58:155–160
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