[HTML][HTML] The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin
S Friis, KU Sales, JM Schafer, LK Vogel… - Journal of Biological …, 2014 - ASBMB
The membrane-anchored serine proteases, matriptase and prostasin, and the membrane-
anchored serine protease inhibitors, hepatocyte growth factor activator inhibitor (HAI)-1 and
HAI-2, are critical effectors of epithelial development and postnatal epithelial homeostasis.
Matriptase and prostasin form a reciprocal zymogen activation complex that results in the
formation of active matriptase and prostasin that are targets for inhibition by HAI-1 and HAI-
2. Conflicting data, however, have accumulated as to the existence of auxiliary functions for …
anchored serine protease inhibitors, hepatocyte growth factor activator inhibitor (HAI)-1 and
HAI-2, are critical effectors of epithelial development and postnatal epithelial homeostasis.
Matriptase and prostasin form a reciprocal zymogen activation complex that results in the
formation of active matriptase and prostasin that are targets for inhibition by HAI-1 and HAI-
2. Conflicting data, however, have accumulated as to the existence of auxiliary functions for …