Ferrokinetics: a biologic model for plasma iron exchange in man

JD Cook, G Marsaglia, JW Eschbach… - The Journal of …, 1970 - Am Soc Clin Investig
JD Cook, G Marsaglia, JW Eschbach, DD Funk, CA Finch
The Journal of Clinical Investigation, 1970Am Soc Clin Investig
A method is presented for calculating internal iron kinetics. An early reflux associated with
extravascular exchange and a late reflux associated with erythropoiesis are described. A
biologic model of iron exchange is proposed in which erythron iron turnover is divided into
an effective portion (iron fixed in circulating red cells) and wastage iron of erythropoiesis
(late reflux). Nonerythroid iron exchange also has a fixed portion (parenchymal uptake) and
an early reflux (lymphatic circuit), both of which correlate in amount with the amount of …
A method is presented for calculating internal iron kinetics. An early reflux associated with extravascular exchange and a late reflux associated with erythropoiesis are described. A biologic model of iron exchange is proposed in which erythron iron turnover is divided into an effective portion (iron fixed in circulating red cells) and wastage iron of erythropoiesis (late reflux). Nonerythroid iron exchange also has a fixed portion (parenchymal uptake) and an early reflux (lymphatic circuit), both of which correlate in amount with the amount of plasma iron. Ferrokinetic measurements in normal subjects and in various pathologic states are presented to validate the model.
The Journal of Clinical Investigation