[HTML][HTML] Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein …
CC Franklin, AS Kraft - Journal of Biological Chemistry, 1997 - ASBMB
Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent
activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase
(SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.
These kinases are regulated by the reversible dual phosphorylation of conserved threonine
and tyrosine residues. The dual specificity protein phosphatase MAPK phosphatase-1 (MKP-
1) has been shown to dephosphorylate and inactivate ERK2, SAPK, and p38 MAPK in …
activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase
(SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.
These kinases are regulated by the reversible dual phosphorylation of conserved threonine
and tyrosine residues. The dual specificity protein phosphatase MAPK phosphatase-1 (MKP-
1) has been shown to dephosphorylate and inactivate ERK2, SAPK, and p38 MAPK in …