The role of persistence in Helicobacter pylori pathogenesis

DA Israel, RM Peek Jr - Current opinion in gastroenterology, 2006 - journals.lww.com
DA Israel, RM Peek Jr
Current opinion in gastroenterology, 2006journals.lww.com
H. pylori persists in its acidic gastric niche, typically for the lifetime of the host. This
persistence increases the risk of diseases such as peptic ulcer disease and gastric cancer.
Delineation of mechanisms that regulate ongoing H. pylori–host interactions will not only
improve targeted diagnostic and therapeutic modalities, but may also provide insights into
other diseases that arise within the context of chronic pathogen infection.
Summary
H. pylori persists in its acidic gastric niche, typically for the lifetime of the host. This persistence increases the risk of diseases such as peptic ulcer disease and gastric cancer. Delineation of mechanisms that regulate ongoing H. pylori–host interactions will not only improve targeted diagnostic and therapeutic modalities, but may also provide insights into other diseases that arise within the context of chronic pathogen infection.
Lippincott Williams & Wilkins