LPS alters placental inflammatory and endocrine mediators and inhibits fetal neurite growth in affected offspring during late gestation
ME Straley, KL Togher, AM Nolan, LC Kenny… - Placenta, 2014 - Elsevier
Introduction During pregnancy, maternal infection at different stages of gestation increases
the risk of developing several psychiatric and neurological disorders later in life for affected
offspring. As placental health is intrinsically linked to neurodevelopmental outcome,
maternal infection may adversely affect the placenta at or before the gestational stages it
affects fetal neurodevelopment. Here we examined this premise. Methods Pregnant-
Sprague Dawley rats were administered saline or lipopolysaccharide by intraperitoneal …
the risk of developing several psychiatric and neurological disorders later in life for affected
offspring. As placental health is intrinsically linked to neurodevelopmental outcome,
maternal infection may adversely affect the placenta at or before the gestational stages it
affects fetal neurodevelopment. Here we examined this premise. Methods Pregnant-
Sprague Dawley rats were administered saline or lipopolysaccharide by intraperitoneal …