[HTML][HTML] The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci
WWY Au, BR Henderson - Journal of Biological Chemistry, 2005 - ASBMB
BRCA1 accumulates in nuclear foci during S-phase and reassembles into DNA repair-
associated foci after DNA damage, reflecting its role in genome maintenance. BRCA1
comprises a RING domain at the N terminus and a BRCT domain at the C terminus, through
which it associates with DNA repair proteins. The key sequences that target BRCA1 to DNA
damage-induced foci have not been identified. Here, we mapped the BRCA1 foci-targeting
domains of yellow fluorescence protein (YFP)-tagged BRCA1 in MCF-7 breast cancer cells …
associated foci after DNA damage, reflecting its role in genome maintenance. BRCA1
comprises a RING domain at the N terminus and a BRCT domain at the C terminus, through
which it associates with DNA repair proteins. The key sequences that target BRCA1 to DNA
damage-induced foci have not been identified. Here, we mapped the BRCA1 foci-targeting
domains of yellow fluorescence protein (YFP)-tagged BRCA1 in MCF-7 breast cancer cells …