Combinatorial cancer immunotherapies

MD Hellmann, CF Friedman, JD Wolchok - Advances in immunology, 2016 - Elsevier
T cell checkpoint blockade therapies are revolutionizing the treatment of patients with
cancer. Highlighted by the recent success of PD-1 plus CTLA-4 blockade in patients with
melanomas, synergistic immunotherapy combinations of modalities represent an important
opportunity to improve responses and outcomes for patients. We review the rationale and
experience with T cell checkpoint blockade in combination with targeting of other
coinhibitory or costimulatory checkpoints, immunomodulatory molecules in the tumor …