New insights into the mechanism of Wnt signaling pathway activation
A Kikuchi, H Yamamoto, A Sato, S Matsumoto - International review of cell …, 2011 - Elsevier
Wnts compromise a large family of secreted, hydrophobic glycoproteins that control a variety
of developmental and adult processes in all metazoan organisms. Recent advances in the
Wnt-signal studies have revealed that distinct Wnts activate multiple intracellular cascades
that regulate cellular proliferation, differentiation, migration, and polarity. Although the
mechanism by which Wnts regulate different pathways selectively remains to be clarified,
evidence has accumulated that in addition to the formation of ligand–receptor pairs …
of developmental and adult processes in all metazoan organisms. Recent advances in the
Wnt-signal studies have revealed that distinct Wnts activate multiple intracellular cascades
that regulate cellular proliferation, differentiation, migration, and polarity. Although the
mechanism by which Wnts regulate different pathways selectively remains to be clarified,
evidence has accumulated that in addition to the formation of ligand–receptor pairs …