[HTML][HTML] Rac1 regulates interleukin 1-induced nuclear factor κB activation in an inhibitory protein κBα-independent manner by enhancing the ability of the p65 subunit …
CA Jefferies, LAJ O'Neill - Journal of Biological Chemistry, 2000 - ASBMB
We have examined the involvement of Rac1 in nuclear factor κB (NFκB) activation by
interleukin 1 (IL1). IL1 induced a rapid and sustained activation of Rac1 in the thymoma cell
line EL4. NOB-1. Transient transfection with dominant negative RacN17 inhibited IL1-
induced κB-dependent reporter gene expression but not IκBα degradation, whereas
constitutively active RacV12 potentiated κB-dependent reporter gene expression in
response to IL1 but had no effects on its own. Using porcine aortic endothelial cells stably …
interleukin 1 (IL1). IL1 induced a rapid and sustained activation of Rac1 in the thymoma cell
line EL4. NOB-1. Transient transfection with dominant negative RacN17 inhibited IL1-
induced κB-dependent reporter gene expression but not IκBα degradation, whereas
constitutively active RacV12 potentiated κB-dependent reporter gene expression in
response to IL1 but had no effects on its own. Using porcine aortic endothelial cells stably …