Tie2 and Eph receptor tyrosine kinase activation and signaling

WA Barton, AC Dalton, TCM Seegar… - Cold Spring …, 2014 - cshperspectives.cshlp.org
WA Barton, AC Dalton, TCM Seegar, JP Himanen, DB Nikolov
Cold Spring Harbor perspectives in biology, 2014cshperspectives.cshlp.org
The Eph and Tie cell surface receptors mediate a variety of signaling events during
development and in the adult organism. As other receptor tyrosine kinases, they are
activated on binding of extracellular ligands and their catalytic activity is tightly regulated on
multiple levels. The Eph and Tie receptors display some unique characteristics, including
the requirement of ligand-induced receptor clustering for efficient signaling. Interestingly,
both Ephs and Ties can mediate different, even opposite, biological effects depending on …
The Eph and Tie cell surface receptors mediate a variety of signaling events during development and in the adult organism. As other receptor tyrosine kinases, they are activated on binding of extracellular ligands and their catalytic activity is tightly regulated on multiple levels. The Eph and Tie receptors display some unique characteristics, including the requirement of ligand-induced receptor clustering for efficient signaling. Interestingly, both Ephs and Ties can mediate different, even opposite, biological effects depending on the specific ligand eliciting the response and on the cellular context. Here we discuss the structural features of these receptors, their interactions with various ligands, as well as functional implications for downstream signaling initiation. The Eph/ephrin structures are already well reviewed and we only provide a brief overview on the initial binding events. We go into more detail discussing the Tie-angiopoietin structures and recognition.
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