Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema–distichiasis syndrome
SL Dagenais, RL Hartsough, RP Erickson… - Gene Expression …, 2004 - Elsevier
The molecular events involved in lymphatic development are poorly understood. Hence, the
genes responsible for hereditary lymphedema are of great interest due to the potential for
providing insights into the mechanisms of lymphatic development, the diagnosis, prevention
and treatment of lymphedema, and lymphangiogenesis during tumor growth. Mutations in
the FOXC2 transcription factor cause a major form of hereditary lymphedema, the
lymphedema–distichiasis syndrome. We have conducted a study of Foxc2 expression …
genes responsible for hereditary lymphedema are of great interest due to the potential for
providing insights into the mechanisms of lymphatic development, the diagnosis, prevention
and treatment of lymphedema, and lymphangiogenesis during tumor growth. Mutations in
the FOXC2 transcription factor cause a major form of hereditary lymphedema, the
lymphedema–distichiasis syndrome. We have conducted a study of Foxc2 expression …