[HTML][HTML] Mouse models for studying the formation and propagation of prions

JC Watts, SB Prusiner - Journal of Biological Chemistry, 2014 - ASBMB
Prions are self-propagating protein conformers that cause a variety of neurodegenerative
disorders in humans and animals. Mouse models have played key roles in deciphering the
biology of prions and in assessing candidate therapeutics. The development of transgenic
mice that form prions spontaneously in the brain has advanced our understanding of
sporadic and genetic prion diseases. Furthermore, the realization that many proteins can
become prions has necessitated the development of mouse models for assessing the …