[HTML][HTML] Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivo
T Matsuoka, H Kaneto, S Kawashima… - Journal of Biological …, 2015 - ASBMB
The murine Mafa transcription factor is a key regulator of postnatal islet β-cell activity,
affecting insulin transcription, insulin secretion, and β-cell mass. Human MAFA expression is
also markedly decreased in islet β-cells of type 2 diabetes mellitus (T2DM) patients.
Moreover, levels are profoundly reduced in db/db islet β-cells, a mouse model of T2DM. To
examine the significance of this key islet β-cell-enriched protein to glycemic control under
diabetic conditions, we generated transgenic mice that conditionally and specifically …
affecting insulin transcription, insulin secretion, and β-cell mass. Human MAFA expression is
also markedly decreased in islet β-cells of type 2 diabetes mellitus (T2DM) patients.
Moreover, levels are profoundly reduced in db/db islet β-cells, a mouse model of T2DM. To
examine the significance of this key islet β-cell-enriched protein to glycemic control under
diabetic conditions, we generated transgenic mice that conditionally and specifically …
