Amyloid β-peptide (Aβ), the pathogenic agent of Alzheimer disease, is a physiological
metabolite whose levels are constantly controlled in normal brain. Recent studies have
demonstrated that a fraction of extracellular Aβ is associated with exosomes, small
membrane vesicles of endosomal origin, although the fate of Aβ in association with
exosome is largely unknown. In this study, we identified novel roles for neuron-derived
exosomes acting on extracellular Aβ, ie exosomes drive conformational changes in Aβ to …